DHSD_XENTR
ID DHSD_XENTR Reviewed; 152 AA.
AC Q6P355;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial;
DE Short=CybS;
DE AltName: Full=Succinate dehydrogenase complex subunit D;
DE AltName: Full=Succinate-ubiquinone oxidoreductase cytochrome b small subunit;
DE AltName: Full=Succinate-ubiquinone reductase membrane anchor subunit;
DE Flags: Precursor;
GN Name=sdhd; ORFNames=TNeu097k19.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Membrane-anchoring subunit of succinate dehydrogenase (SDH)
CC that is involved in complex II of the mitochondrial electron transport
CC chain and is responsible for transferring electrons from succinate to
CC ubiquinone (coenzyme Q). {ECO:0000250}.
CC -!- SUBUNIT: Component of complex II composed of four subunits: the
CC flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome
CC b560 composed of sdhc and sdhd. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CybS family. {ECO:0000305}.
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DR EMBL; CR848414; CAJ82461.1; -; mRNA.
DR EMBL; BC064178; AAH64178.1; -; mRNA.
DR RefSeq; NP_989357.1; NM_204026.1.
DR AlphaFoldDB; Q6P355; -.
DR SMR; Q6P355; -.
DR STRING; 8364.ENSXETP00000057629; -.
DR PaxDb; Q6P355; -.
DR DNASU; 394986; -.
DR Ensembl; ENSXETT00000057629; ENSXETP00000057629; ENSXETG00000027683.
DR GeneID; 394986; -.
DR KEGG; xtr:394986; -.
DR CTD; 6392; -.
DR Xenbase; XB-GENE-5855162; sdhd.
DR eggNOG; KOG4097; Eukaryota.
DR HOGENOM; CLU_096618_1_1_1; -.
DR InParanoid; Q6P355; -.
DR OMA; QGGRHIH; -.
DR OrthoDB; 1511215at2759; -.
DR PhylomeDB; Q6P355; -.
DR TreeFam; TF313310; -.
DR Reactome; R-XTR-71403; Citric acid cycle (TCA cycle).
DR Proteomes; UP000008143; Chromosome 7.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000027683; Expressed in skeletal muscle tissue and 18 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005749; C:mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); ISS:UniProtKB.
DR GO; GO:0020037; F:heme binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048039; F:ubiquinone binding; ISS:UniProtKB.
DR GO; GO:0006121; P:mitochondrial electron transport, succinate to ubiquinone; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR CDD; cd03496; SQR_TypeC_CybS; 1.
DR Gene3D; 1.20.1300.10; -; 1.
DR InterPro; IPR007992; CybS.
DR InterPro; IPR034804; SQR/QFR_C/D.
DR PANTHER; PTHR13337; PTHR13337; 1.
DR SUPFAM; SSF81343; SSF81343; 1.
PE 2: Evidence at transcript level;
KW Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix; Transport; Tricarboxylic acid cycle.
FT TRANSIT 1..21
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 22..152
FT /note="Succinate dehydrogenase [ubiquinone] cytochrome b
FT small subunit, mitochondrial"
FT /id="PRO_0000343810"
FT TOPO_DOM 22..56
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 57..78
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 79..83
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 105..113
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250"
FT TRANSMEM 114..135
FT /note="Helical"
FT /evidence="ECO:0000250"
FT TOPO_DOM 136..152
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250"
FT BINDING 95
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_note="ligand shared with sdhc"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250|UniProtKB:A5GZW8"
FT BINDING 107
FT /ligand="a ubiquinone"
FT /ligand_id="ChEBI:CHEBI:16389"
FT /ligand_note="ligand shared with IP/sdhb"
FT /evidence="ECO:0000250"
SQ SEQUENCE 152 AA; 16424 MW; 0BD78A972A707B12 CRC64;
MATLLRVSSL CRANRASAFK SLLIRPVPCL TQDHHMVQTS QIHTSPNHHA GSKAASMHWT
SERALSVALL GLLPAAYLYP GAAMDYSLAA ALTLHGHWGL GQVVTDYVHG DAKIKMANTS
LFALSALTFA GLCYFNYHDV GICKAVSMLW SL
