DHRSX_MOUSE
ID DHRSX_MOUSE Reviewed; 335 AA.
AC Q8VBZ0; B2RRV9; Q3TZW6;
DT 03-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Dehydrogenase/reductase SDR family member on chromosome X homolog;
DE EC=1.1.-.-;
DE AltName: Full=DHRSXY;
DE AltName: Full=SCAD family protein;
GN Name=Dhrsx; Synonyms=Pscad;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-280.
RC STRAIN=FVB/N; TISSUE=Embryo;
RX PubMed=11731500; DOI=10.1101/gr.197001;
RA Gianfrancesco F., Sanges R., Esposito T., Tempesta S., Rao E., Rappold G.,
RA Archidiacono N., Graves J.A.M., Forabosco A., D'Urso M.;
RT "Differential divergence of three human pseudoautosomal genes and their
RT mouse homologs: implications for sex chromosome evolution.";
RL Genome Res. 11:2095-2100(2001).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in the positive regulation of starvation-induced
CC autophagy. {ECO:0000250|UniProtKB:Q8N5I4}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8N5I4}.
CC Note=Secreted in a non-classical form. A signal peptide sequence at
CC position 1-23 is predicted. {ECO:0000250|UniProtKB:Q8N5I4}.
CC -!- MISCELLANEOUS: Autosomal gene, which is the ortholog of human DHRSX,
CC located at the termini of the long and short arms of the X and Y
CC chromosomes.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; AK157461; BAE34091.1; -; mRNA.
DR EMBL; BC138597; AAI38598.1; -; mRNA.
DR EMBL; BC138599; AAI38600.1; -; mRNA.
DR EMBL; AJ296079; CAC82539.1; -; mRNA.
DR AlphaFoldDB; Q8VBZ0; -.
DR SMR; Q8VBZ0; -.
DR STRING; 10090.ENSMUSP00000076472; -.
DR iPTMnet; Q8VBZ0; -.
DR PhosphoSitePlus; Q8VBZ0; -.
DR EPD; Q8VBZ0; -.
DR MaxQB; Q8VBZ0; -.
DR PaxDb; Q8VBZ0; -.
DR PeptideAtlas; Q8VBZ0; -.
DR PRIDE; Q8VBZ0; -.
DR ProteomicsDB; 279529; -.
DR UCSC; uc009vdc.1; mouse.
DR MGI; MGI:2181510; Dhrsx.
DR eggNOG; KOG1208; Eukaryota.
DR InParanoid; Q8VBZ0; -.
DR PhylomeDB; Q8VBZ0; -.
DR PRO; PR:Q8VBZ0; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8VBZ0; protein.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0010508; P:positive regulation of autophagy; ISS:UniProtKB.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 1: Evidence at protein level;
KW Oxidoreductase; Reference proteome; Secreted.
FT CHAIN 1..335
FT /note="Dehydrogenase/reductase SDR family member on
FT chromosome X homolog"
FT /id="PRO_0000031975"
FT ACT_SITE 208
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 47..71
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT BINDING 183
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CONFLICT 131
FT /note="G -> A (in Ref. 3; CAC82539)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="H -> Q (in Ref. 3; CAC82539)"
FT /evidence="ECO:0000305"
FT CONFLICT 247
FT /note="L -> M (in Ref. 3; CAC82539)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 335 AA; 35957 MW; A191AC1BA9065F85 CRC64;
MSTLRALRAV LCVYAVGIAV ALAQLLRRLR GDFRPPVLPP QPGRVAIVTG ATAGIGRSTA
RQLARLGMCV VVAGNDEHRG QEVVSSIRAE MGSDRAHFLP LDLASLASVR GFARDFQALG
LPLHLLVNNA GVMLEPRAET EDGFERHLGV NFLGHFLLTL LLLPALRASG AEGRGSRVVT
VGSATHYVGT VDMADLHGRH AYSPYAAYAQ SKLALALFAL QLQRILDARG DPVTSNMADP
GVVDTELYRH AGWVLRTAKR FLGWLVFKSP EEGAWTLVYA AAAPELEGVG GRYLRDEAEA
EPLGTARDQE LQRRLWAEGL RLTGAGGGDS DGVAW
