DHR13_HUMAN
ID DHR13_HUMAN Reviewed; 377 AA.
AC Q6UX07; B4DJC5; Q96BH7;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Dehydrogenase/reductase SDR family member 13;
DE EC=1.1.-.- {ECO:0000305};
DE AltName: Full=Short chain dehydrogenase/reductase family 7C member 5 {ECO:0000303|PubMed:19027726};
DE Short=Protein SDR7C5 {ECO:0000303|PubMed:19027726};
DE Flags: Precursor;
GN Name=DHRS13 {ECO:0000312|HGNC:HGNC:28326};
GN Synonyms=SDR7C5 {ECO:0000303|PubMed:19027726}; ORFNames=UNQ419/PRO853;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Subthalamic nucleus {ECO:0000312|EMBL:BAG58787.1};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19027726; DOI=10.1016/j.cbi.2008.10.040;
RA Persson B., Kallberg Y., Bray J.E., Bruford E., Dellaporta S.L.,
RA Favia A.D., Duarte R.G., Joernvall H., Kavanagh K.L., Kedishvili N.,
RA Kisiela M., Maser E., Mindnich R., Orchard S., Penning T.M., Thornton J.M.,
RA Adamski J., Oppermann U.;
RT "The SDR (short-chain dehydrogenase/reductase and related enzymes)
RT nomenclature initiative.";
RL Chem. Biol. Interact. 178:94-98(2009).
CC -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6UX07-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UX07-2; Sequence=VSP_029640;
CC Name=3;
CC IsoId=Q6UX07-3; Sequence=VSP_057529;
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; AY358566; AAQ88929.1; -; mRNA.
DR EMBL; AK296017; BAG58787.1; -; mRNA.
DR EMBL; AC024267; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471159; EAW51159.1; -; Genomic_DNA.
DR EMBL; CH471159; EAW51153.1; -; Genomic_DNA.
DR EMBL; BC015582; AAH15582.1; -; mRNA.
DR CCDS; CCDS11246.2; -. [Q6UX07-1]
DR RefSeq; NP_653284.2; NM_144683.3. [Q6UX07-1]
DR AlphaFoldDB; Q6UX07; -.
DR SMR; Q6UX07; -.
DR BioGRID; 127030; 36.
DR IntAct; Q6UX07; 5.
DR STRING; 9606.ENSP00000368173; -.
DR iPTMnet; Q6UX07; -.
DR PhosphoSitePlus; Q6UX07; -.
DR BioMuta; DHRS13; -.
DR DMDM; 74738164; -.
DR EPD; Q6UX07; -.
DR jPOST; Q6UX07; -.
DR MassIVE; Q6UX07; -.
DR MaxQB; Q6UX07; -.
DR PaxDb; Q6UX07; -.
DR PeptideAtlas; Q6UX07; -.
DR PRIDE; Q6UX07; -.
DR ProteomicsDB; 4366; -.
DR ProteomicsDB; 67548; -. [Q6UX07-1]
DR ProteomicsDB; 67549; -. [Q6UX07-2]
DR TopDownProteomics; Q6UX07-1; -. [Q6UX07-1]
DR Antibodypedia; 14931; 83 antibodies from 15 providers.
DR DNASU; 147015; -.
DR Ensembl; ENST00000378895.9; ENSP00000368173.4; ENSG00000167536.14. [Q6UX07-1]
DR Ensembl; ENST00000394901.7; ENSP00000378361.3; ENSG00000167536.14. [Q6UX07-2]
DR Ensembl; ENST00000426464.2; ENSP00000412826.2; ENSG00000167536.14. [Q6UX07-3]
DR GeneID; 147015; -.
DR KEGG; hsa:147015; -.
DR MANE-Select; ENST00000378895.9; ENSP00000368173.4; NM_144683.4; NP_653284.2.
DR UCSC; uc002hdd.5; human. [Q6UX07-1]
DR UCSC; uc010wba.3; human.
DR CTD; 147015; -.
DR DisGeNET; 147015; -.
DR GeneCards; DHRS13; -.
DR HGNC; HGNC:28326; DHRS13.
DR HPA; ENSG00000167536; Tissue enhanced (bone).
DR MIM; 616157; gene.
DR neXtProt; NX_Q6UX07; -.
DR OpenTargets; ENSG00000167536; -.
DR PharmGKB; PA147358144; -.
DR VEuPathDB; HostDB:ENSG00000167536; -.
DR eggNOG; KOG1208; Eukaryota.
DR GeneTree; ENSGT00940000155599; -.
DR HOGENOM; CLU_010194_44_5_1; -.
DR InParanoid; Q6UX07; -.
DR OMA; NRPVVGW; -.
DR OrthoDB; 1076292at2759; -.
DR PhylomeDB; Q6UX07; -.
DR TreeFam; TF105429; -.
DR PathwayCommons; Q6UX07; -.
DR SignaLink; Q6UX07; -.
DR BioGRID-ORCS; 147015; 19 hits in 1084 CRISPR screens.
DR ChiTaRS; DHRS13; human.
DR GenomeRNAi; 147015; -.
DR Pharos; Q6UX07; Tdark.
DR PRO; PR:Q6UX07; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6UX07; protein.
DR Bgee; ENSG00000167536; Expressed in blood and 103 other tissues.
DR Genevisible; Q6UX07; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0052650; F:NADP-retinol dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0042574; P:retinal metabolic process; IBA:GO_Central.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; NAD; NADP; Oxidoreductase; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..377
FT /note="Dehydrogenase/reductase SDR family member 13"
FT /id="PRO_0000311920"
FT REGION 309..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 197
FT /note="Proton acceptor"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 46
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 48
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 170
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 197
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 201
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 232
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT VAR_SEQ 1..50
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_029640"
FT VAR_SEQ 43..123
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_057529"
FT VARIANT 191
FT /note="R -> Q (in dbSNP:rs2277666)"
FT /id="VAR_037348"
FT VARIANT 336
FT /note="L -> Q (in dbSNP:rs4795472)"
FT /id="VAR_037349"
SQ SEQUENCE 377 AA; 40849 MW; 742688974BBDA564 CRC64;
MEALLLGAGL LLGAYVLVYY NLVKAPPCGG MGNLRGRTAV VTGANSGIGK MTALELARRG
ARVVLACRSQ ERGEAAAFDL RQESGNNEVI FMALDLASLA SVRAFATAFL SSEPRLDILI
HNAGISSCGR TREAFNLLLR VNHIGPFLLT HLLLPCLKAC APSRVVVVAS AAHCRGRLDF
KRLDRPVVGW RQELRAYADT KLANVLFARE LANQLEATGV TCYAAHPGPV NSELFLRHVP
GWLRPLLRPL AWLVLRAPRG GAQTPLYCAL QEGIEPLSGR YFANCHVEEV PPAARDDRAA
HRLWEASKRL AGLGPGEDAE PDEDPQSEDS EAPSSLSTPH PEEPTVSQPY PSPQSSPDLS
KMTHRIQAKV EPEIQLS
