ID   DHR13_BOVIN             Reviewed;         377 AA.
AC   Q17QU7;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Dehydrogenase/reductase SDR family member 13;
DE            EC=1.1.-.- {ECO:0000305};
DE   AltName: Full=Short chain dehydrogenase/reductase family 7C member 5 {ECO:0000250|UniProtKB:Q6UX07};
DE            Short=Protein SDR7C5 {ECO:0000250|UniProtKB:Q6UX07};
DE   Flags: Precursor;
GN   Name=DHRS13; Synonyms=SDR7C5 {ECO:0000250|UniProtKB:Q6UX07};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative oxidoreductase. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC118170; AAI18171.1; -; mRNA.
DR   RefSeq; NP_001069155.1; NM_001075687.1.
DR   AlphaFoldDB; Q17QU7; -.
DR   SMR; Q17QU7; -.
DR   STRING; 9913.ENSBTAP00000017950; -.
DR   PaxDb; Q17QU7; -.
DR   PRIDE; Q17QU7; -.
DR   Ensembl; ENSBTAT00000017950; ENSBTAP00000017950; ENSBTAG00000013501.
DR   GeneID; 514903; -.
DR   KEGG; bta:514903; -.
DR   CTD; 147015; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013501; -.
DR   VGNC; VGNC:28042; DHRS13.
DR   eggNOG; KOG1208; Eukaryota.
DR   GeneTree; ENSGT00940000155599; -.
DR   HOGENOM; CLU_010194_44_5_1; -.
DR   InParanoid; Q17QU7; -.
DR   OMA; NRPVVGW; -.
DR   OrthoDB; 1076292at2759; -.
DR   TreeFam; TF105429; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000013501; Expressed in retina and 97 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0052650; F:NADP-retinol dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0042574; P:retinal metabolic process; IBA:GO_Central.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   NAD; NADP; Oxidoreductase; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..377
FT                   /note="Dehydrogenase/reductase SDR family member 13"
FT                   /id="PRO_0000311919"
FT   REGION          310..363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        197
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         46
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         48
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         170
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         197
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         201
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
FT   BINDING         232
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250|UniProtKB:Q99714"
SQ   SEQUENCE   377 AA;  40861 MW;  DFDE3FC67AE90850 CRC64;
     MEALLLGVGL LLGAYVLVYY NLVKAPPCRG LASLRGRTAV VTGANSGIGK MTALELARRG
     ARVVLACRSR ERGEAAAFDL RQESGNNEVI FMALDLASLA SVRAFATAFL SSEPRLDILI
     HNAGISSCGR TREPFNLLLR VNHIGPFLLT HLLLPRLKTS APSRVVVVSS AAHRRGRLDF
     TRLDHPVVGW QQELRAYANS KLANVLFARE LATQLEGTGV TCYAAHPGPV NSELFLRHVP
     GWLRPLLRPL AWLVLRAPRG GAQTPLYCAL QEGIEPLSGR YFANCHVEEV PPAARDDRAA
     HRLWEASRKL AGLGPGEDAE SDEDSQPEDP GTPSSPSSPH PEEPTVSELY PSPQSSTDRS
     TVTCRIPVKA ELEPQAC