DHR12_BOVIN
ID DHR12_BOVIN Reviewed; 317 AA.
AC A6QP05;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Dehydrogenase/reductase SDR family member 12 {ECO:0000250|UniProtKB:A0PJE2};
DE EC=1.1.-.- {ECO:0000305};
DE AltName: Full=Short-chain dehydrogenase/reductase family 40C member 1 {ECO:0000250|UniProtKB:A0PJE2};
DE Short=Protein SDR40C1 {ECO:0000250|UniProtKB:A0PJE2};
GN Name=DHRS12; Synonyms=SDR40C1 {ECO:0000250|UniProtKB:A0PJE2};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hippocampus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative oxidoreductase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC149086; AAI49087.1; -; mRNA.
DR RefSeq; NP_001093783.1; NM_001100313.1.
DR AlphaFoldDB; A6QP05; -.
DR SMR; A6QP05; -.
DR STRING; 9913.ENSBTAP00000021443; -.
DR PaxDb; A6QP05; -.
DR Ensembl; ENSBTAT00000021443; ENSBTAP00000021443; ENSBTAG00000016109.
DR GeneID; 507276; -.
DR KEGG; bta:507276; -.
DR CTD; 79758; -.
DR VEuPathDB; HostDB:ENSBTAG00000016109; -.
DR VGNC; VGNC:28041; DHRS12.
DR eggNOG; KOG1208; Eukaryota.
DR GeneTree; ENSGT00940000163782; -.
DR HOGENOM; CLU_010194_44_8_1; -.
DR InParanoid; A6QP05; -.
DR OrthoDB; 1076292at2759; -.
DR TreeFam; TF353029; -.
DR Proteomes; UP000009136; Chromosome 12.
DR Bgee; ENSBTAG00000016109; Expressed in saliva-secreting gland and 103 other tissues.
DR ExpressionAtlas; A6QP05; baseline and differential.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; SSF51735; 1.
PE 2: Evidence at transcript level;
KW NAD; NADP; Oxidoreductase; Reference proteome.
FT CHAIN 1..317
FT /note="Dehydrogenase/reductase SDR family member 12"
FT /id="PRO_0000312174"
FT ACT_SITE 201
FT /note="Proton acceptor"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 50
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 52
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 175
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 201
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 205
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
FT BINDING 234
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250|UniProtKB:Q99714"
SQ SEQUENCE 317 AA; 35065 MW; 23A0AE87232FD64E CRC64;
MLLYRSAAWF AKGLREYTKS GYESASKDFV PDDLEVQVPG RAFMVTGGNS GIGKATAMEI
AKRGGTVHLV CRDHSRAEGA KAEIIRESGN QNIFLHIVDL SLPKSVWKFV ENFKQEHTLN
VLINNAGCMV NKRELTEDGL EKNFATNTLG VYVLTTALIP VLEKEHDPRV ITVSSGGMLV
QKLNTDDPQS ERTAFDGTMV YAQNKRQQVV LTERWARAHP AIHFSCMHPG WVDTPGVRLS
MPGFHARLGA RLRSEAQGAD TVLWLALAPA ATAQPSGCFF QDRKPAPTHL PLARTSSSPA
EEEKLIEILE ELARRFK
