DHI1L_CHICK
ID DHI1L_CHICK Reviewed; 287 AA.
AC Q6PUF4;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Hydroxysteroid 11-beta-dehydrogenase 1-like protein;
DE EC=1.1.1.-;
DE AltName: Full=11-beta-hydroxysteroid dehydrogenase type 3;
DE Short=11-DH3;
DE Short=11-beta-HSD3;
DE Flags: Precursor;
GN Name=HSD11B1L; Synonyms=HSD3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang C.Q., Zhou J.L., Wu S.L.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; AY578179; AAS89255.1; -; mRNA.
DR RefSeq; NP_001001201.1; NM_001001201.1.
DR AlphaFoldDB; Q6PUF4; -.
DR SMR; Q6PUF4; -.
DR STRING; 9031.ENSGALP00000020944; -.
DR Ensembl; ENSGALT00000020974; ENSGALP00000020944; ENSGALG00000012860.
DR GeneID; 408034; -.
DR KEGG; gga:408034; -.
DR CTD; 374875; -.
DR VEuPathDB; HostDB:geneid_408034; -.
DR eggNOG; KOG1205; Eukaryota.
DR GeneTree; ENSGT00940000162487; -.
DR HOGENOM; CLU_010194_2_7_1; -.
DR InParanoid; Q6PUF4; -.
DR OMA; ITKDWFP; -.
DR OrthoDB; 906746at2759; -.
DR PhylomeDB; Q6PUF4; -.
DR PRO; PR:Q6PUF4; -.
DR Proteomes; UP000000539; Chromosome 28.
DR Bgee; ENSGALG00000012860; Expressed in kidney and 13 other tissues.
DR ExpressionAtlas; Q6PUF4; baseline.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 2: Evidence at transcript level;
KW NADP; Oxidoreductase; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..287
FT /note="Hydroxysteroid 11-beta-dehydrogenase 1-like protein"
FT /id="PRO_0000316818"
FT ACT_SITE 183
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 41..67
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 92..93
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 119..121
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 170
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 183..187
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 216..222
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
SQ SEQUENCE 287 AA; 31479 MW; 3F89ABFDD802B27F CRC64;
MMKPFGKVLC AAGSLAVLLA FFWRDTFQPE QLSGARVLLT GASAGIGEQM AYHYATFGAE
IVLTARREAV LQEVMKKCLT LGAKKVFYIP ADMSSPSEPD RVVQFAVQNL GGLDYLVLNH
IGVSPFQMWG GDVEHTRWLM QVNFFSYVAL ATAALPTLEK NHGSVVVVSS LTGKIPTPFT
TSYSATKFAL DGFFSSLRHE LTMQKRNVSI TLCILGLIDT DAALEKTRGK VFIAASPAAE
AALAIIRGGA ARLRELFYPW WLQPVHGLWV LLPNPRVLQS FYNYSGP
