ID   DFFB_BOVIN              Reviewed;         341 AA.
AC   Q58CZ0;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=DNA fragmentation factor subunit beta;
DE            EC=3.-.-.-;
GN   Name=DFFB;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Nuclease that induces DNA fragmentation and chromatin
CC       condensation during apoptosis. Degrades naked DNA and induces apoptotic
CC       morphology (By similarity). {ECO:0000250}.
CC   -!- ACTIVITY REGULATION: Inhibited by DFFA (DFF45). Interacts with
CC       HIST1H1A. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of DFFA and DFFB (By similarity). Interacts with
CC       H1-1 (By similarity). {ECO:0000250|UniProtKB:O76075}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; BT021807; AAX46654.1; -; mRNA.
DR   RefSeq; NP_001030281.1; NM_001035109.1.
DR   AlphaFoldDB; Q58CZ0; -.
DR   SMR; Q58CZ0; -.
DR   STRING; 9913.ENSBTAP00000026657; -.
DR   PaxDb; Q58CZ0; -.
DR   GeneID; 512730; -.
DR   KEGG; bta:512730; -.
DR   CTD; 1677; -.
DR   eggNOG; ENOG502R0RF; Eukaryota.
DR   InParanoid; Q58CZ0; -.
DR   OrthoDB; 1254881at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004536; F:deoxyribonuclease activity; IBA:GO_Central.
DR   GO; GO:0004520; F:endodeoxyribonuclease activity; IEA:InterPro.
DR   GO; GO:0006309; P:apoptotic DNA fragmentation; IBA:GO_Central.
DR   InterPro; IPR003508; CIDE-N_dom.
DR   InterPro; IPR039729; DFF40.
DR   InterPro; IPR015311; DFF40_C.
DR   InterPro; IPR044925; His-Me_finger_sf.
DR   PANTHER; PTHR13067; PTHR13067; 1.
DR   Pfam; PF02017; CIDE-N; 1.
DR   Pfam; PF09230; DFF40; 1.
DR   SMART; SM00266; CAD; 1.
DR   SUPFAM; SSF54060; SSF54060; 1.
DR   PROSITE; PS51135; CIDE_N; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Hydrolase; Nuclease; Nucleus; Reference proteome.
FT   CHAIN           1..341
FT                   /note="DNA fragmentation factor subunit beta"
FT                   /id="PRO_0000244030"
FT   DOMAIN          7..83
FT                   /note="CIDE-N"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00447"
SQ   SEQUENCE   341 AA;  38967 MW;  708AB4B22ED8EEAF CRC64;
     MSAVLRKPKT FKLRSLHSEK KFGVAGRSCE EVLRKGCQRL QLPIPGSRLC LYEDGTELTG
     DYFWSAPDNS ELVLLTAGQT WQGFVSDISR FLSVFQEPHA GVIQAARQLL WDERAPLRQK
     LLADLLGTVS ENIAAETRAE DPPWFEGLES RFRSKSGYLR YSCESRIRSY LREVTSGASL
     VGAEAREEYL RLVGSMQQKL QAAQYNSSYF DRGAKAGRRL CTPEGWFSCQ GPFDVDDCTS
     RHSINPYSNR ESRVLFSTWN LDHVIEKKRV VVPALAAAVH DAEGREVDWE YFYRLLFTLE
     NLKLVHIACH KKTTHKLHCD PSRVYCTPAA PRRKRHARHR L