ID   DESR_MEGGA              Reviewed;          37 AA.
AC   P00273;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Desulforedoxin;
DE            Short=DX;
GN   Name=dsr;
OS   Megalodesulfovibrio gigas (Desulfovibrio gigas).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfovibrionaceae; Megalodesulfovibrio.
OX   NCBI_TaxID=879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2254288; DOI=10.1128/jb.172.12.7289-7292.1990;
RA   Brumlik M.J., Leroy G., Bruschi M., Voordouw G.;
RT   "The nucleotide sequence of the Desulfovibrio gigas desulforedoxin gene
RT   indicates that the Desulfovibrio vulgaris rbo gene originated from a gene
RT   fusion event.";
RL   J. Bacteriol. 172:7289-7292(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-37.
RX   PubMed=508323; DOI=10.1016/0006-291x(79)91277-4;
RA   Bruschi M., Moura I., le Gall J., Xavier A.V., Sieker L.C.;
RT   "The amino acid sequence of desulforedoxin, a new type of non heme iron
RT   protein from Desulfovibrio gigas.";
RL   Biochem. Biophys. Res. Commun. 90:596-605(1979).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
RX   PubMed=7666420; DOI=10.1006/jmbi.1995.0465;
RA   Archer M., Huber R., Tavares P., Moura I., Moura J.J., Carrondo M.A.,
RA   Sieker L.C., Legall J., Romao M.J.;
RT   "Crystal structure of desulforedoxin from Desulfovibrio gigas determined at
RT   1.8-A resolution: a novel non-heme iron protein structure.";
RL   J. Mol. Biol. 251:690-702(1995).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
RX   PubMed=10422844; DOI=10.1110/ps.8.7.1536;
RA   Archer M., Carvalho A.L., Teixeira S., Moura I., Moura J.J.G., Rusnak F.,
RA   Romao M.J.;
RT   "Structural studies by X-ray diffraction on metal substituted
RT   desulforedoxin, a rubredoxin-type protein.";
RL   Protein Sci. 8:1536-1545(1999).
RN   [5]
RP   STRUCTURE BY NMR.
RA   Goodfellow B.J., Tavares P., Romao M.J., Czaja C., Rusnak F., Legall J.,
RA   Moura I., Moura J.J.;
RT   "The solution structure of desulforedoxin, a simple iron-sulfur protein. An
RT   NMR study of the zinc derivative.";
RL   J. Biol. Inorg. Chem. 1:341-354(1996).
RN   [6]
RP   STRUCTURE BY NMR.
RX   PubMed=9568899; DOI=10.1002/pro.5560070410;
RA   Goodfellow B.J., Rusnak F., Moura I., Dommke T., Moura J.J.;
RT   "NMR determination of the global structure of the 113Cd derivative of
RT   desulforedoxin: investigation of the hydrogen bonding pattern at the metal
RT   center.";
RL   Protein Sci. 7:928-937(1998).
CC   -!- FUNCTION: Nonheme iron protein possibly involved in electron transport.
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC       Note=Binds 2 irons ions per subunit via 4 cysteine residues per iron.;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: To the N-terminal section of desulfoferrodoxin.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M62784; AAA23365.1; -; Genomic_DNA.
DR   PIR; A37857; SDDVEG.
DR   PDB; 1CFW; X-ray; 1.90 A; A/B=2-37.
DR   PDB; 1DCD; X-ray; 2.00 A; A/B=2-37.
DR   PDB; 1DHG; X-ray; 2.50 A; A/B=2-37.
DR   PDB; 1DXG; X-ray; 1.80 A; A/B=2-37.
DR   PDB; 2LK5; NMR; -; A/B=2-37.
DR   PDB; 2LK6; NMR; -; A/B=2-37.
DR   PDBsum; 1CFW; -.
DR   PDBsum; 1DCD; -.
DR   PDBsum; 1DHG; -.
DR   PDBsum; 1DXG; -.
DR   PDBsum; 2LK5; -.
DR   PDBsum; 2LK6; -.
DR   AlphaFoldDB; P00273; -.
DR   BMRB; P00273; -.
DR   SMR; P00273; -.
DR   EvolutionaryTrace; P00273; -.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   Gene3D; 2.20.28.100; -; 1.
DR   InterPro; IPR004462; Desulfoferrodoxin_N.
DR   InterPro; IPR038094; Desulfoferrodoxin_N_sf.
DR   InterPro; IPR012002; Desulforedoxin.
DR   Pfam; PF06397; Desulfoferrod_N; 1.
DR   PIRSF; PIRSF000075; Desulforedoxin; 1.
DR   TIGRFAMs; TIGR00319; desulf_FeS4; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Electron transport; Iron;
KW   Metal-binding; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:508323"
FT   PEPTIDE         2..37
FT                   /note="Desulforedoxin"
FT                   /id="PRO_0000044734"
FT   BINDING         10
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   BINDING         13
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   BINDING         29
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   BINDING         30
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   STRAND          7..9
FT                   /evidence="ECO:0007829|PDB:1DXG"
FT   TURN            11..13
FT                   /evidence="ECO:0007829|PDB:1DXG"
FT   STRAND          16..21
FT                   /evidence="ECO:0007829|PDB:1DXG"
FT   STRAND          27..29
FT                   /evidence="ECO:0007829|PDB:1DXG"
SQ   SEQUENCE   37 AA;  3936 MW;  6F6C3B2CD93CAA4F CRC64;
     MANEGDVYKC ELCGQVVKVL EEGGGTLVCC GEDMVKQ