9-Decyn-1-ol

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9-Decyn-1-ol

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CAS NO:

17643-36-6

9-Decyn-1-ol 是一种 PROTAC linker，属于 alkyl/ether 类，可用于合成一系列 PROTAC 分子，如 9-Decyn-1-ol 将 GDC-0068 和 Lenalidomide 偶联可合成 INY-03-041 (HY-133120)。INY-03-041 是一种有效的选择性 PROTAC Akt 降解剂。INY-03-041 抑制 Akt1，Akt2 和 Akt3，IC₅₀分别为 2.0 nM，6.8 nM 和 3.5 nM。

生物活性

9-Decyn-1-ol is an alkyl/ether-basedPROTAClinker that can be used in the synthesis ofPROTACs. 9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibitsAkt1,Akt2andAkt3with IC₅₀s of 2.0 nM, 6.8 nM and 3.5 nM, respectively^[1].

IC₅₀& Target^[1]

Alkyl/ether

体外研究
(In Vitro)

9-Decyn-1-ol can be used to conjugate GDC-0068 with Lenalidomide to generate INY-03-041. INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker^[1].

分子量

154.25

性状

Liquid

Formula

C₁₀H₁₈O

CAS 号

17643-36-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month