ALDH1A3-IN-1 (Compound 14) 是一个有效的ALDH1A3抑制剂，其IC50值为 0.63 μM，Ki值为 0.46 μM。ALDH1A3-IN-1 能被用于研究前列腺癌 (prostate cancer)。
| 生物活性 | ALDH1A3-IN-1 (Compound 14) is a potentALDH1A3inhibitor, with anIC50of 0.63 μM and aKiof 0.46 μM. ALDH1A3-IN-1 can be studied inprostatecancer[1]. |
| IC50& Target | ALDH1A3 0.63 μM (IC50) | ALDH1A1 7.08 μM (IC50) | ALDH3A1 8.00 μM (IC50) | ALDH1A3 0.46 μM (Ki) | ALDH1A3 26.92 μM (Km) |
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体外研究
(In Vitro) | ALDH1A3-IN-1 (Compound 14) (0-200 μM, 96 h) shows antiproliferative activity in prostate cancer cell lines[1].
ALDH1A3-IN-1 (0-200 μM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner[1].
Cell Proliferation Assay[1] | Cell Line: | PC3, LNCaP, and DU145 cells | | Concentration: | 12.5-200 μM | | Incubation Time: | 96 h | | Result: | Showed antiproliferative activity with IC50values of 47 ± 6, 25 ± 1, and 61 ± 5 μM against PC3, LNCaP, and DU145 cells. |
Cell Viability Assay[1] | Cell Line: | Primary cells cultured at early passage from human prostate tissue biopsies | | Concentration: | 50 and 200 μM | | Incubation Time: | 72 h | | Result: | Resulted a dose-dependent reduction in percentage cell viability of primary prostate epithelial cultures. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
