AZD 3988 是一种具有口服活性的 diacylglycerol acyl transferase-1 (DGAT-1) 抑制剂。
| Cas No. | 892489-52-0 |
| 别名 | 反式-4-[4-[[[5-[(3,4-二氟苯基)氨基]-1,3,4-恶二唑-2-基]羰基]氨基]苯基]环己烷乙酸 |
| 化学名 | 5-((3,4-difluorophenyl)amino)-N-(4-((1r,4r)-4-methylcyclohexyl)phenyl)-1,3,4-oxadiazole-2-carboxamide compound with methanedione (1:1) |
| Canonical SMILES | O=C(C1=NN=C(NC2=CC(F)=C(F)C=C2)O1)NC(C=C3)=CC=C3[C@@H]4CC[C@@H](C[H])CC4.O=C=O |
| 分子式 | C23H22F2N4O4 |
| 分子量 | 456.44 |
| 溶解度 | <45.64mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | AZD3988 is a diacylglycerol acyl transferase-1 (DGAT-1) inhibitor with IC50s of 6, 5, 11 nM for human, rat, mouse, respectively[1]. References:
[1]. McCoull W, et al. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3873-8. |
