R18 is a peptide antagonists of14-3-3, with a K_Dof 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinaseRaf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation ofRaf-1^[1].

2309.69

C₁₀₁H₁₅₇N₂₇O₂₉S₃

211364-78-2

Pro-His-Cys-Val-Pro-Arg-Asp-Leu-Ser-Trp-Leu-Asp-Leu-Glu-Ala-Asn-Met-Cys-Leu-Pro

PHCVPRDLSWLDLEANMCLP

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.