pan-HER-IN-2 (Compound C6) 是一种可逆的、具有口服活性的广谱HER抑制剂。对EGFR、HER4、EGFRT790M/L858R和HER2的IC50分别为 0.72、2.0、8.2 和 75.1 nM。pan-HER-IN-2 诱导细胞凋亡 (apoptosis)，表现出抗肿瘤活性。
| 生物活性 | pan-HER-IN-2 (Compound C6) is a reversible, orally active pan-HERinhibitor withIC50values of 0.72, 2.0, 8.2 and 75.1 nM againstEGFR,HER4,EGFRT790M/L858RandHER2, respectively. pan-HER-IN-2 inducesapoptosisand shows antitumor activities[1]. |
| IC50& Target | EGFR 0.72 nM (IC50) | EGFR (L858R/T790M) 8.2 nM (IC50) | HER2 75.1 nM (IC50) | HER4 2.0 nM (IC50) |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
