pan-HER-IN-1 (Compound C5) 是一种不可逆的、具有口服活性的广谱HER抑制剂。对EGFR、HER4、EGFRT790M/L858R和HER2的IC50分别为 0.38、1.6、2.2 和 3.5 nM。pan-HER-IN-1 诱导细胞凋亡 (apoptosis)，表现出抗肿瘤活性。
| 生物活性 | pan-HER-IN-1 (Compound C5) is an irreversible, orally active pan-HERinhibitor withIC50values of 0.38, 1.6, 2.2 and 3.5 nM againstEGFR,HER4,EGFRT790M/L858RandHER2, respectively. pan-HER-IN-1 inducesapoptosisand shows antitumor activities[1]. |
| IC50& Target | EGFR 0.38 nM (IC50) | HER4 1.6 nM (IC50) | EGFRL858R/T790M/C797S 2.2 nM (IC50) | HER2 3.5 nM (IC50) |
|
| 分子量 | |
| Formula | |
| CAS 号 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
