COR170

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COR170

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1048039-15-1

COR170 (11u) 是一种选择性的CB2反向激动剂，是一种 4-喹诺酮-3-羧酸衍生物，对 CB2 的K_i值为 3.8 nM。COR170 可用于炎症和神经保护的研究。

生物活性

COR170 (11u) is a selectiveCB2inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with aK_ivalue of 3.8 nM forCB2receptor. COR170 can be used for the research of inflammation and neuroprotection^[1]^[2]^[3].

体外研究
(In Vitro)

COR170 (11u) (0-1 μM) inhibits CB2 receptor in HEK cell membranes with aK_ivalue of 3.8 nM^[2].

体内研究
(In Vivo)

COR170 (11u) (1.5-6 mg/kg; i.p, once) reduces the late phase nociceptive behaviour induced by formalin^[3].

Animal Model:	Mice with formalin (1.25%, 30 μL) injections^[3]
Dosage:	1.5, 3 and 6 mg/kg
Administration:	Intraperitoneal injection; 1.5, 3 and 6 mg/kg for once
Result:	Reduced the late phase nociceptive behaviour induced by formalin with a 6 mg/kg dose and 10 min before formalin and abolished the analgesic effect from GW405833 which is a CB₂receptor partial agonist.

分子量

468.63

Formula

C₃₁H₃₆N₂O₂

CAS 号

1048039-15-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.