SLV 320 (SLV 320) 是一种有效、选择性和口服活性的腺苷 A1 受体拮抗剂，对人 A1、A3 和 A2A 受体的 Ki 值分别为 1 nM、200 nM 和 398 nM。
| Cas No. | 251945-92-3 |
| 别名 | (1R,4R)-4-(2-苯基-7H-吡咯并[2,3-D]嘧啶-4-氨基)环己醇,SLV 320 |
| 化学名 | (1s,4s)-4-((2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexanol |
| Canonical SMILES | O[C@H]1CC[C@H](CC1)NC2=NC(C3=CC=CC=C3)=NC4=C2C=CN4 |
| 分子式 | C18H20N4O |
| 分子量 | 308.38 |
| 溶解度 | <30.84mg/ml in DMSO;<15.42mg/ml in ethanol |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1]. References:
[1]. Kalk P, et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32. |
