Perospirone hydrochloride

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CAS NO:

129273-38-7

SM-9018

Perospirone hydrochloride (SM-9018) 是具有口服活性的5-HT_2A受体 (K_i为 0.6 nM) 和多巴胺D₂受体 (K_i为 1.4 nM) 的拮抗剂，也是5-HT_1A受体 (K_i为 2.9 nM) 的部分激动剂。Perospirone hydrochloride 是一种非典型的抗精神病剂，可用于精神分裂症的研究。

生物活性

Perospirone hydrochloride (SM-9018) is an orally active antagonist of5-HT_2Areceptor (K_iof 0.6 nM) anddopamine D₂receptor (K_iof 1.4 nM). Perospirone hydrochloride is also a partial agonist of5-HT_1Areceptor (K_iof 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research^[1]^[2].

IC₅₀& Target^[1]^[2]

5-HT_2AReceptor

0.6 nM (Ki)

D₂Receptor

1.4 nM (Ki)

5-HT_1AReceptor

2.9 nM (Ki)

5-HT₁Receptor

18 nM (Ki)

D₁Receptor

41 nM (Ki)

Clinical Trial

分子量

463.04

Formula

C₂₃H₃₁ClN₄O₂S

CAS 号

129273-38-7

中文名称

盐酸哌罗匹隆

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.