TC-E 5001 是一种Wnt通路抑制剂，通过新型腺苷袋结合抑制端锚聚合酶 1/2 (TNKS1/2)，Kds 值分别为 79 和 28 nM。TC-E 5001 还抑制Axin2和STF，IC50值分别为 0.709 μM 和 0.215 μM。
| 生物活性 | TC-E 5001 is an inhibitor ofWntpathwaythat inhibitstankyrase 1/2 (TNKS1/2)via novel adenosine pocket binding, withKds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibitsAxin2andSTF, withIC50s of 0.709 μM and 0.215 μM, respectively[1][2]. |
| IC50& Target[1] | TNKS1 79 nM (Ki) | TNKS2 28 nM (Ki) |
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体外研究
(In Vitro) | TC-E 5001 inhibits TNKS2, with an IC50of 33 nM[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
