YK5

立即咨询

YK5

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1268273-23-9

YK5 是一种有效的选择性Hsp70抑制剂。YK5 在癌细胞中选择性地，紧密地与胞质 Hsp70s 结合。YK5 通过干扰活性致癌 Hsp70/Hsp90/ 配体蛋白复合物的形成而发挥其生物活性。

生物活性

YK5 is a potent and selectiveHsp70inhibitor. YK5 selectively and tightly binds to the cytosolic Hsp70s incancercells. YK5 has biological activity partly by interfering with the formation of active oncogenic Hsp70/Hsp90/client protein complexes^[1].

IC₅₀& Target

HSP70

HSP90

体外研究
(In Vitro)

YK5 shows selectively and tightly binds to the cytosolic Hsp70s^[1].
YK5 (0.5, 1, 5 μM; 72 h) degrades the expression of Hsp90/Hsp70-onco-client proteins and also leads to the inhibition of cell proliferation in SKBr3 cells^[1].
YK5 (0.5, 1, 5 μM; 24 h) induces the degradation of HER2, Raf-1, Akt kinases, and also induces apoptosis in SKBr3 cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	SKBr3 cells
Concentration:	0.5, 1, 5 μM
Incubation Time:	72 h
Result:	Degraded the expression of Hsp90/Hsp70-onco-client proteins and also led to the inhibition of cell proliferation in SKBr3 cells.

Western Blot Analysis^[1]

Cell Line:	SKBr3 cells
Concentration:	0.5, 1, 5 μM
Incubation Time:	24 h
Result:	Induced the degradation of HER2, Raf-1, Akt kinases, and also induced apoptosis in SKBr3 cells.

分子量

432.50

Formula

C₁₈H₂₄N₈O₃S

CAS 号

1268273-23-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.