HDAC-IN-42

立即咨询

HDAC-IN-42

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2454024-18-9

HDAC-IN-42 (compound 14f) 是一种有效的选择性HDAC抑制剂，对 HDAC1 和 HDAC6 的IC₅₀值分别为 0.19 和 4.98 μM。HDAC-IN-42 显示出抗癌和抗增殖活性。HDAC-IN-42 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。

生物活性

HDAC-IN-42 (compound 14f) is a potent and selectiveHDACinhibitor withIC₅₀values of 0.19 and 4.98 μM forHDAC1andHDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 inducesapoptosisand cell cycle arrest at G2/M phase^[1].

IC₅₀& Target^[1]

HDAC1

0.19 μM (IC₅₀)

HDAC6

4.98 μM (IC₅₀)

体外研究
(In Vitro)

HDAC-IN-42 (compound 14f) shows anti-proliferative activity with C₅₀s of 9.56, 13.32, 10.46, 6.91 μM for MCF-7, HCT-116, HepG2, Hela cells, respectively^[1].
HDAC-IN-42 (1, 5, 10 μM; 24 h) reduces the colony formation and increases the expression of histone H3 and α-tubulin in HeLa cells^[1].
HDAC-IN-42 (1, 5, 10 μM; 48 h) induces apoptosis and cell cycle arrest at G2/M phase^[1].

分子量

381.34

Formula

C₂₀H₁₅NO₇

CAS 号

2454024-18-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.