ZLHQ-5f

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ZLHQ-5f

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

ZLHQ-5f 是一种CDK2和Topo I双重抑制剂，对 CDK2/CycA2 的IC₅₀值为 0.145 μM。ZLHQ-5f 在 S 期阻滞细胞周期，诱导 HCT116 细胞凋亡 (apoptosis)，具有良好安全性。

生物活性

ZLHQ-5f is a dualCDK2andTopo Iinhibitor with anIC₅₀of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggersapoptosisin HCT116 cells, and has a good safety profile^[1].

IC₅₀& Target

CDK2/CycA2

0.145 μM (IC₅₀)

Top1

体外研究
(In Vitro)

ZLHQ-5f shows antiproliferative activity with GI₅₀values of 0.949 ± 0.113, 0.821 ± 0.240, 1.124 ± 0.362, 1.945 ± 0.278 and 3.349 ± 0.149 μM against A549, HCT116, MCF-7, HepG2 and LO2 cells, respectively^[1].

分子量

463.53

Formula

C₂₈H₂₅N₅O₂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.