Aurora kinase inhibitor-10

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CAS NO:

2417228-90-9

Aurora kinase inhibitor-10 (Compound 6c) 是一种具有口服活性的Aurora B抑制剂，IC₅₀为 8 nM。Aurora kinase inhibitor-10 具有抗肿瘤活性。

生物活性

Aurora kinaseinhibitor-10 (Compound 6c) is an orally activeAurora Binhibitor with anIC₅₀of 8 nM.Aurora kinaseinhibitor-10 shows antitumor activity^[1].

IC₅₀& Target

Aurora B

8 nM (IC₅₀)

体外研究
(In Vitro)

Aurora kinase inhibitor-10 (Compound 6c) shows antiproliferation activity with IC₅₀values of 0.57 ± 0.23, 0.42 ± 0.20, 0.69 ± 0.30, 3.97 ± 0.67 and 1.53 ± 0.52 μM against MCF-7, MDA-MB 231, SkoV3, A375 and A549, respectively^[1].

分子量

546.47

Formula

C₂₁H₁₉F₅N₆O₄S

CAS 号

2417228-90-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.