ATR-IN-12 (Compound 5g) 是一种有效的共济失调毛细血管扩张和 Rad3 相关 (ATR) 激酶抑制剂，IC50值 0.007 μM。ATR-IN-12 显示出良好的抗肿瘤活性并显着降低 ATR 及其下游信号蛋白的磷酸化水平。ATR-IN-12 是一种很有前途的先导化合物，可用于后续针对 ATR 激酶的药物发现。
| 生物活性 | ATR-IN-12 (Compound 5g) is a potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase with anIC50value of 0.007 μM. ATR-IN-12 displays good anti-tumor activity and significantly reduces the phosphorylation level ofATRand its downstream signaling protein. ATR-IN-12 is a promising lead compound for subsequent drug discovery targetingATRkinase[1]. |
| 分子量 | |
| Formula | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
