Antitumor agent-63

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Antitumor agent-63

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1627600-90-1

Antitumor agent-63 (Compound 40)，20 (S)-O-linked camptothecin (CPT) 糖复合物，是一种抗肿瘤剂，对正常细胞无毒性。Antitumor agent-63 具有高稳定性和很弱的topoisomerase I (Topo I)直接抑制效果。

生物活性

Antitumor agent-63 (Compound 40), a 20 (S)-O-linked camptothecin (CPT) glycoconjugate, is an antitumor agent without toxicity towards normal cells. Antitumor agent-63 shows high stability and very weak directtopoisomeraseI (Topo I)inhibition^[1].

IC₅₀& Target

Top1

体外研究
(In Vitro)

Antitumor agent-63 (Compound 40) shows cytotoxicity activities with IC₅₀values of 1.2, 0.8, 30.5 and >100 μM against HepG2, HCT-116, SW1990 and HEK-293, respectively^[1].

分子量

846.79

Formula

C₃₈H₄₆N₄O₁₈

CAS 号

1627600-90-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.