Bcl-2-IN-2 是一种有效的选择性Bcl-2抑制剂，IC50为 0.034 nM，也可抑制 Bcl-xL，IC50为 43 nM，对 Bcl-2 的活性是 Bcl-xL 的 1000多倍。
| 生物活性 | Bcl-2-IN-2 is a potent and selectiveBcl-2inhibitor with anIC50of 0.034 nM and also inhibitsBcl-xLwith an IC50of 43 nM, showing >1000-fold selectivity forBcl-2overBcl-xL[1]. |
| IC50& Target[1] | Bcl-2 0.034 nM (IC50) | Bcl-xL 43 nM (IC50) |
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体外研究
(In Vitro) | Bcl-2-IN-2 inhibits mutant Bcl-2-G101V with an IC50of 1.2 nM. Bcl-2-IN-2 inhibits RS4;11 cellular proliferation with an IC50of 1.9 nM[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
