Propargyl-PEG2-NHBoc

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CAS NO:

869310-84-9

Propargyl-PEG2-NHBoc 是一种可降解 (cleavable) 的ADClinker，用于抗体偶联药物 (ADCs) 的合成。Propargyl-PEG2-NHBoc 是一种PROTAC linker，属于 PEG 类。Propargyl-PEG2-NHBoc 可用于合成一系列 PROTAC 分子。

生物活性

Propargyl-PEG2-NHBoc is acleavableADC linkerused in the synthesis ofantibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-basedPROTAClinkercan be used in the synthesis ofPROTACs^[1].

IC₅₀& Target^[1]

Cleavable

PEGs

Alkyl/ether

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

分子量

243.30

性状

Liquid

Formula

C₁₂H₂₁NO₄

CAS 号

869310-84-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month