Mitapivat (AG-348) 是一种具有口服活性的丙酮酸激酶变构激活剂。
| Cas No. | 1260075-17-9 |
| 别名 | AG-348 |
| Canonical SMILES | O=S(C1=C2N=CC=CC2=CC=C1)(NC3=CC=C(C(N4CCN(CC5CC5)CC4)=O)C=C3)=O |
| 分子式 | C24H26N4O3S |
| 分子量 | 450.55 |
| 溶解度 | DMSO : 50 mg/mL (110.98 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Mitapivat is a potent human R-type pyruvate kinase (PKR) inhibitor; also shows potency for mutant PKR including R510Q PKR, R532W PKR, T384W PKR etc. References:
[1]. PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY. Patent WO/2012/151451A1 |
