Boc-NH-PEG1-CH2CH2COOH is acleavable(1 unit PEG)ADC linkerand also aPEG- andAlkyl/ether-basedPROTAClinkercan be used in the synthesis ofantibody-drug conjugates (ADCs)orPROTACs^[1][2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

233.26

Solid

C₁₀H₁₉NO₅

1260092-44-1

Room temperature in continental US; may vary elsewhere.