Bulaquine

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Bulaquine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

79781-00-3

CDRI 80/53
Elubaquine

Bulaquine (CDRI 80/53) 是有效的抗疟疾剂，是 Primaquine (HY-12651A) 的类似物。Bulaquine 影响多条代谢途径，对Plasmodium cynomolgi感染有抑制作用。Bulaquine 可用于疟疾的研究。

生物活性

Bulaquine (CDRI 80/53) is a potentantimalarial agentwhich is an analogue ofPrimaquine(HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect onPlasmodiumcynomolgiinfection. Bulaquine can be used for the research of malaria^[1]^[2]^[3].

IC₅₀& Target

Plasmodium

体内研究
(In Vivo)

Bulaquine (40 mg/kg; p.o. once) affects multiple pathways in vivo^[1].
Bulaquine (1.25 mg/kg; once daily; for 7 days) shows 100% curative anti-relapse activity with a primaquine index of 0.8 for rhesus monkeys withPlasmodium cynomolgiB infection^[2].

Animal Model:	25-30 g male Swiss albino mice^[1]
Dosage:	40 mg/kg
Administration:	Oral gavage; 40 mg/kg once
Result:	Affected oxidative stress and fatty acid synthesis pathway, apoptosis, cell cycle, inflammatory response, glycogen metabolism, Kreb’s cycle, electron transport chain, fatty acid β-oxidation, MAPK signalling, signalling of hepatocyte growth factor receptor, matrix metalloproteinases, steroid biosynthesis, TGF-β signalling, translation factors, Wnt signalling, regulation of actin cytoskeleton, ribosomal proteins, RNA transcription reactome, proteasome degradation and nuclear receptors in lipid metabolism according to GO results.

分子量

369.46

Formula

C₂₁H₂₇N₃O₃

CAS 号

79781-00-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.