Bleomycin

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Bleomycin

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CAS NO:

11056-06-7

Bleomycin 是一种糖肽抗生素。Bleomycin 对一系列的淋巴瘤、头颈部癌症和生殖细胞肿瘤具有强大的抗肿瘤活性。Bleomycin 可用于癌症和化疗的研究。

生物活性

Bleomycin is aglycopeptideantibiotic. Bleomycin has potent antitumour activities against a range of lymphomas, head and neck cancers and germ-cell tumours. Bleomycin can be used for the research ofcancerand chemotherapy^[1]^[2]^[3]^[4].

IC₅₀& Target

Glycopeptide

体外研究
(In Vitro)

Bleomycin (0-4 mU/mL; 1 h) induces double-strand break in V79 cells^[2].
Bleomycin (0-1 mU/mL; 1 h) reduces migration of DNA from S-phase cells^[2].
Bleomycin (0-3 μg/mL; 1 h) induces chromatid aberrations in G2 cells^[3].

体内研究
(In Vivo)

Bleomycin (1 mg and 10 μg; retro-orbitary sinus injection once) affects cells in mitosis, induces apoptosis in tumor models^[4].

Animal Model:	C57Bl/6 mice with LPB and B16F0 tumours^[4]
Dosage:	1 mg and 10 μg
Administration:	Retro-orbitary sinus injection; 1 mg and 10 μg once
Result:	Decreased in the fraction of cells in mitosis in both tumours, induced cell apoptosis after the electric pulses delivery, inceased the amount of atypical cells in LPB tumours.

Clinical Trial

CAS 号

11056-06-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.