ODN 24987

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ODN 24987

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1682661-48-8

ODN 24987 是一种鸟嘌呤修饰的抑制性寡核苷酸 (ODN)，靶向TLR9。ODN 24987 可抑制 IL-6 和 IFN-α 的释放。ODN 24987 可用于研究免疫紊乱。ODN 24987 序列：5’-C-C-T-G-G-C-c7G-G-G-G-3’。

生物活性

ODN 24987 is a Guanine-modified inhibitoryoligonucleotides(ODN), targetingTLR9. ODN 24987 can inhibitIL-6and IFN-α release. ODN 24987 can be used for research immune disorders. ODN 24987 sequence: 5’-C-C-T-G-G-C-c7G-G-G-G-3’^[1].

IC₅₀& Target^[1]

TLR9

体外研究
(In Vitro)

ODN 24987 (0.1, 1 and 10 μM, 24 h) impairs efficiently TLR9-mediated release of IFN-α by PBMCs, and prevents IL-6 release by CpG-ODN-activated human B-cells^[1].
ODN 24987 (0.01, 0.1, 1, 10 μM; 48 h) impairs Imiquimod-induced IL-6 release by human PBMCs^[1].

性状

Solid

CAS 号

1682661-48-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)