Sphingosine-1-phosphate is an extracellular lipid mediator whose major effects are mediated through five distinct G protein-coupled receptors, S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8. S1P2 has been implicated in multiple biological functions, including Rho activation, inhibition of Rac and cell migration, and in “feed forward” autocrine signaling in NF-κB survival signaling of tumor cells.[1] CYM 5520 is a noncompetitive allosteric agonist of S1P2 (EC50 = 0.48 μM) that does not display agonist activity towards S1P1, S1P3, S1P4, or S1P5.[1]

Reference:
[1]. Satsu, H., Schaeffer, M.T., Guerrero, M., et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorganic & Medicinal Chemistry 21(17), 5373-5382 (2013).