SGK1-IN-3 (compound 3a) 是一种有效的、具有口服活性的SGK1抑制剂。丝氨酸/苏氨酸激酶 SGK1 是 β-连环蛋白途径的激活剂，是软骨降解的强大刺激剂，在患病的骨关节炎软骨中被发现在基因组控制下被上调。SGK1-IN-3具有研究骨关节炎的潜力。
| 生物活性 | SGK1-IN-3 (compound 3a) is a potent and orally active inhibitor ofSGK1. Theserine/threonine kinaseSGK1 is an activator of theβ-cateninpathway and a powerful stimulator of cartilage degradation that is found to be upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 has the potential for the research of osteoarthritis[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
