Bococizumab

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Bococizumab

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1407495-02-6

PF-04950615
RN316

Bococizumab (PF-04950615) 是一种抗-人 PCSK9 的抗体抑制剂，可降低低密度脂蛋白胆固醇 (LDL-C) 水平。Bococizumab 可用于高胆固醇血症的研究。

生物活性

Bococizumab (PF-04950615) is an anti-human PCSK9 inhibitory antibody that reduces LDLcholesterollevels. Bococizumab can be used in the research of hypercholesterolemia^[1]^[2].

IC₅₀& Target

PCSK9^[1]

体内研究
(In Vivo)

Bococizumab (0-100 mg/kg, i.v.) decreases maternal and fetal cholesterol and does not affect rat embryo-fetal development^[2].

Animal Model:	Pregnant Sprague-Dawley (SD) rats^[1]
Dosage:	0, 10, 30, and 100 mg/kg
Administration:	Intravenous injection (i.v.)
Result:	Decreased in fetal cholesterol levels. Showed well tolerance and no effects on ovarian or uterine parameters.

Clinical Trial

性状

Liquid

CAS 号

1407495-02-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.