Lonidamine (AF-1890) 是一种己糖激酶和线粒体丙酮酸载体抑制剂（Ki:2.5 μM）。
| Cas No. | 50264-69-2 |
| 别名 | 氯尼达明; AF-1890; Diclondazolic Acid; DICA |
| 化学名 | 1-[(2,4-dichlorophenyl)methyl]indazole-3-carboxylic acid |
| Canonical SMILES | C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O |
| 分子式 | C15H10Cl2N2O2 |
| 分子量 | 321.16 |
| 溶解度 | ≥ 11.1mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Lonidamine (AF-1890), an antitumor agent, is a hexokinase, mitochondrial pyruvate carrier (Ki 2.5 μM in isolated rat liver mitochondria) and plasma membrane monocarboxylate transporters inhibitor, which also inhibits mitochondrial complex II[1][2]. References:
[1]. Guo L, et al. Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine. J Biol Chem. 2016 Jan 1;291(1):42-57.
[2]. Nancolas B, et al. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016 Apr 1;473(7):929-36. |
