JNc-440

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JNc-440

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1119503-63-7

JNc-440 是一种有效的抗高血压剂。JNc-440 可增强内皮细胞瞬时受体电位香草酸亚型 4 (TRPV4) 和钙离子激活钾通道 3 (KCa2.3) 的相互作用。JNc-440 还能增强小鼠血管扩张，具有降压作用。

生物活性

JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction ofTRPV4and Ca²⁺-activatedpotassium channel3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice^[1].

体内研究
(In Vivo)

JNc-440 (1 mg/kg; IV; single dosage) improves endothelium-dependent relaxation in small resistance arteries and to lower blood pressure^[1].

Animal Model:	TRPV4^-/-and wild‐ ype C57BL/6J mice (hypertensive induced by NOS inhibitor Nω-nitro-L-arginine, AngII and high-salt diet)^[1]
Dosage:	1 mg/kg
Administration:	IV; single dosage
Result:	Increased the impaired TRPV4‐KCa2.3 interaction to improve endothelium‐dependent relaxation in small resistance arteries and to lower blood pressure.

分子量

440.49

性状

Solid

Formula

C₂₆H₂₄N₄O₃

CAS 号

1119503-63-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month