DCEBIO 是 1-EBIO 的衍生物，是 T84 结肠细胞中 Cl-分泌的极强激活剂 。
| Cas No. | 60563-36-2 |
| 别名 | 5,6-2氯-1-乙基-1H-苯并咪唑-2酮 |
| 化学名 | 5,6-dichloro-1-ethyl-1H-benzo[d]imidazol-2(3H)-one |
| Canonical SMILES | ClC(C=C(C(NC1=O)=C2)N1CC)=C2Cl |
| 分子式 | C9H8Cl2N2O |
| 分子量 | 231.08 |
| 溶解度 | <23.11mg/ml in ethanol;<23.11mg/ml in DMSO |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl－ secretion in T84 colonic cells[1]. DCEBIO stimulates Cl－ secretion via the activation of hIK1 K＋ channels and the activation of an apical membrane Cl－ conductance[2]. References:
[1]. Hamilton KL,et al. DCEBIO stimulates Cl- secretion in the mouse jejunum. Am J Physiol Cell Physiol. 2006 Jan;290(1):C152-64.
[2]. Singh S, et al. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11. |
