YAP/TAZ inhibitor-2

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YAP/TAZ inhibitor-2

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2762617-31-0

YAP/TAZ inhibitor-2 是一种有效的具有口服活性的TEAD-YAP/TAZ抑制剂，EC₅₀值为 3 nM。YAP/TAZ inhibitor-2 显示出抗增殖活性。YAP/TAZ inhibitor-2 显示出抗肿瘤活性。

生物活性

YAP/TAZ inhibitor-2 is a potent and orally activeTEAD-YAP/TAZinhibitor with anEC₅₀value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative activity. YAP/TAZ inhibitor-2 shows antitumor activity^[1].

IC₅₀& Target

EC₅₀: 3 nM (TEAD-YAP/TAZ)^[1]

体外研究
(In Vitro)

YAP/TAZ inhibitor-2 (compound 5) (0-20000 nM; 24 h) shows antiproliferative activity with an IC₅₀value of 5.33 nM in NCI-H226 cells^[1].

体内研究
(In Vivo)

YAP/TAZ inhibitor-2 (0.5, 2, 5, 50 mg/kg; p.o.; daily for 28 days) shows anti-tumor activity with no significant body weight loss during the treatment in BALB/c nude mice (NCI-H226 xenograft model)^[1].

分子量

390.33

性状

Solid

Formula

C₁₉H₁₄F₄N₄O

CAS 号

2762617-31-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(256.19 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.5619 mL	12.8097 mL	25.6193 mL
5 mM	0.5124 mL	2.5619 mL	5.1239 mL
10 mM	0.2562 mL	1.2810 mL	2.5619 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。