GNE-4997 是一种有效选择性的白细胞介素 2 诱导的 T 细胞激酶(ITK)抑制剂，Ki为 0.09 nM，GNE-4997 中可溶性元素碱度与靶外抗增殖作用的相关性降低了细胞毒性。
| 生物活性 | GNE-4997 is a potent and selectiveinterleukin-2-inducible T-cell kinase (ITK)inhibitor with aKiof 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity[1]. |
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体外研究
(In Vitro) | GNE-4997 inhibits PLC-γ phosphorylation in Jurkat cells by T-cell receptor stimulation with an IC50of 4 nM[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
