TSPO Ligand-Linker Conjugates 1

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TSPO Ligand-Linker Conjugates 1 包含转运蛋白 (TSPO) 的配体和连接子，可用来合成靶向线粒体的自噬靶向嵌合体 (AUTAC)。AUTAC 可与线粒体外膜 (OMM) 上的 TSPO 结合，并通过线粒体自噬 (mitophagy) 降解受损的线粒体和蛋白质，并提高线粒体活性。TSPO Ligand-Linker Conjugates 1 可用于线粒体功能紊乱的相关研究，如神经退行性疾病、癌症和糖尿病。

生物活性

TSPO Ligand-Linker Conjugates 1 contains a ligand for translocator protein (TSPO) and a linker, which is used for the synthesis of mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC can bind the TSPO on the outer mitochondrial membrane (OMM) of mitochondria and degrades impaired mitochondria and proteins viamitophagy, and improves mitochondrial activity. TSPO Ligand-Linker Conjugates 1 can be used in mitochondrial dysfunction related research, including neurodegenerative diseases,cancer, and diabetes^[1].

体外研究
(In Vitro)

AUTAC (0-100 μM, 24 h) realizes targeted degradation of endogenous proteins in HeLa cells (MetAP2, FKBP12)^[1].
AUTAC (10 μM, 10 h) reverses mitochondrial dysfunction via K63-Linked ubiquitination in HeLa cells^[1].

Western Blot Analysis^[1]

Cell Line:	HeLa cells
Concentration:	0.1, 1, 10, 100 μM
Incubation Time:	24 h
Result:	AUTAC degraded endogenous proteins (MetAP2, FKBP12).

分子量

673.86

Formula

C₃₂H₅₅N₃O₁₀S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.