Curcumenol ((+)-Curcumenol) 是一种有效的 CYP3A4 抑制剂，IC50 为 12.6 μM，是具有重要药用价值的姜黄属植物的成分之一，具有神经保护、抗炎、抗肿瘤和保肝活动。
| Cas No. | 19431-84-6 |
| 别名 | 莪术醇,(+)-Curcumenol |
| Canonical SMILES | CC([C@@]1([H])[C@]([C@@H](C)CC1)(O2)C/3)=C[C@]2(O)C3=C(C)/C |
| 分子式 | C15H22O2 |
| 分子量 | 234.3 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 5 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 0.3 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Curcumenol ((+)-Curcumenol) is a potent CYP3A4 inhibitor with an IC50 of 12.6 μM, which is one of constituents in the plants of medicinally important genus of Curcuma zedoaria, with neuroprotection, anti-inflammatory, anti-tumor and hepatoprotective activities. Curcumenol ((+)-Curcumenol) suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells[1][2]. References:
[1]. Sun DX, et al. Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes. Phytother Res. 2010 Aug;24(8):1213-6.
[2]. Lo JY, et al. Curcumenol isolated from Curcuma zedoaria suppresses Akt-mediated NF-κB activation and p38 MAPK signaling pathway in LPS-stimulated BV-2 microglial cells. Food Funct. 2015 Nov;6(11):3550-9. |
