15-acetoxyscirpenol 是 acetoxyscirpenol moiety mycotoxins (ASM) 的一种，它通过激活其他不依赖于 caspase-3 的半胱天冬酶以剂量依赖性方式强烈诱导细胞凋亡并抑制 Jurkat T 细胞生长。
| Cas No. | 2623-22-5 |
| 别名 | 15-乙酰蛇形菌素 |
| 化学名 | 12,13-epoxy-trichothec-9-ene-3α,4β,15-triol, 15-acetate |
| Canonical SMILES | CC1=C[C@]2([H])[C@]([C@]([C@H](O)[C@H]3O)(C)[C@@]4(OC4)[C@]3([H])O2)(COC(C)=O)CC1 |
| 分子式 | C17H24O6 |
| 分子量 | 324.4 |
| 溶解度 | ≤10mg/ml in methanol;10mg/ml in dichloromethane |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 15-acetoxy Scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the Fusarium genus [1]. 15-acetoxy Scirpenol could induce apoptotic cell death in human Jurkat T cells. Mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus Fusarium. Acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy Scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). The 50% inhibitory concentration (IC50) values of 15-acetoxy Scirpenol was 16.1 ng/ml [2]. In the Jurkat T cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-MAS), the populations of externalized PS-positive and PI-negative cells were 32.0% [2]. References:
[1] Peraica M, Radic B, Lucic A, et al. Toxic effects of mycotoxins in humans[J]. Bulletin of the World Health Organization, 1999, 77(9): 754-766.
[2] Lee D H, Park T, Kim H W. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins[J]. Biological and Pharmaceutical Bulletin, 2006, 29(4): 648-654. |
