CD73-IN-14

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CD73-IN-14

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2407356-67-4

CD73-IN-14 是一种有效、选择性和具有口服活性的CD73抑制剂，IC₅₀值为 0.17 nM。CD73-IN-14 增加肿瘤浸润性 CD8⁺细胞数量并显示出抗肿瘤活性。

生物活性

D73-IN-14 is a potent, selective and orally activeCD73inhibitor with anIC₅₀value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8⁺cells and shows anti-tumor activity^[1].

IC₅₀& Target

C₅₀: 0.17 nM (CD73)^[1]

体内研究
(In Vivo)

CD73-IN-14 (10, 25, 50 mg/kg; p.o.; twice-a-day for 20 days) shows anti-tumor activity in mouse^[1].br/>Pharmacokinetic Parameters of CD73-IN-14 in rats^[1].

PO Dose (mg/kg)	AUC_{0-24 h}(ng*hr/mL)	C_max(nM)	T_max(hr)
50	580	74	0.8
200	6094	1800	0.8
500	18500	11000	0.3

rats, 50, 200, 500 mg/kg p.o.^[1]

Animal Model:	C57BL/6 mice (EG7 model)^[1]
Dosage:	10, 25, 50 mg/kg
Administration:	P.o.; twice a day for 20 days
Result:	Increased tumor-infiltrating CD8+ cells and decreased the tumor volume in a dose dependet manner.

分子量

615.98

Formula

C₂₆H₂₆ClN₇O₉

CAS 号

2407356-67-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.