CCG-271423 是一种有效的选择性GRK5抑制剂，GRK5 和 GRK2 的IC50值分别为 0.0021 μM 和 44 μM。CCG-271423 抑制心肌细胞收缩能力，降低 Ca2+瞬态。
| 生物活性 | CCG-271423 is a potent and selectiveGRK5inhibitor withIC50values of 0.0021 μM and 44 μM for GRK5 and GRK2, respectively. CCG-271423 inhibits cardiomyocyte contractility and decreases in Ca2+transience[1]. |
| IC50& Target | IC50: 0.0021 μM (GRK5) and 44 μM (GRK5)[1] |
体外研究
(In Vitro) | CCG-271423 (1 μM) does not alter cardiomyocyte contractility and decreases in Ca2+transience[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
