CCG-273463 是一种有效的、共价的GRK5选择性抑制剂，IC50值为 8.6 nM。CCG-273463 可用于心力衰竭、肥厚型心肌病和癌症的研究。
| 生物活性 | CCG-273463 is a potent, selective and covalentGRK5inhibitor with anIC50value of 8.6 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, andcancer[1]. |
| IC50& Target | IC50: 8.6 nM (GRK5), 12 μM (GRK2)[1]. |
体外研究
(In Vitro) | CCG-273463 (0.02-1 μM) potently and highly inhibits GRK5 (IC50: 8.6 nM), with inhibitory rate of 93% (GRK5) and 97% (GRK6) at 1 μM[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
