MST-312 是一种端粒酶抑制剂。 MST-312 是绿茶表没食子儿茶素没食子酸酯 (EGCG) 的化学改性衍生物。 MST-312可用于癌症研究，例如多发性骨髓瘤（MM）。
| Cas No. | 313397-13-6 |
| 别名 | CBLC4H10 |
| 化学名 | N-(3-morpholinopropyl)-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide |
| Canonical SMILES | O=C(C1=C(N=C(C2=CC=CC=C2)C=C3C4=CC=CC=C4)N3N=C1)NCCCN5CCOCC5 |
| 分子式 | C26H27N5O2 |
| 分子量 | 441.52 |
| 溶解度 | <11.04mg/ml in DMSO |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Reversan (CBLC4H10) is a potent and nontoxic multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (Pgp) inhibitor[1][2]. References:
[1]. Tivnan A, et al. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015 Jun 16;9:218.
[2]. Burkhart CA, et al. Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 2009 Aug 15;69(16):6573-80. |
