VU 591 hydrochloride 是一种有效的、选择性的肾外髓质钾通道 (ROMK 或 Kir1.1) 抑制剂，IC50 为 0.24 μM。
| Cas No. | 1315380-70-1 |
| 化学名 | 2,2'-(oxybis(methylene))bis(6-nitro-1H-benzo[d]imidazole) hydrochloride |
| Canonical SMILES | O=N(C1=CC(N2)=C(N=C2COCC3=NC4=C(N3)C=C(N(=O)=O)C=C4)C=C1)=O.Cl |
| 分子式 | C16H12N6O5.HCl |
| 分子量 | 404.76 |
| 溶解度 | <36.83mg/ml in DMSO |
| 储存条件 | Desiccate at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM[1]. References:
[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50. |
