Rubiadin-1-methyl ether 是巴戟天中的蒽醌类化合物，可抑制破骨细胞性骨吸收，通过抑制 NF-κB p65 磷酸化水平，降解 IκBα 蛋白，以及降低 p65 的核转位起作用。
| Cas No. | 7460-43-7 |
| 别名 | 甲基异茜草素-1-甲醚 |
| Canonical SMILES | O=C1C2=C(C=CC=C2)C(C3=CC(O)=C(C)C(OC)=C13)=O |
| 分子式 | C16H12O4 |
| 分子量 | 268.26 |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65[1]. [1]. He YQ, et al. Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway. Biochem Biophys Res Commun. 2018 Dec 2;506(4):927-931. |
