dmDNA31 是一种利福霉素类抗生素，可抑制细菌 DNA 依赖性 RNA 聚合酶，对金黄色葡萄球菌 (S. aureus) 具有强大的杀菌活性。
| Cas No. | 845625-44-7 |
| Canonical SMILES | O=C1C2=C(O[C@@]1(O/C=C\[C@]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@@H](O)[C@@H](C)/C=C/C=C(C)/C3=O)C)O)C)OC(C)=O)C)([H])OC)C)C(C)=C(O)C4=C2C(C(OC5=CC(N6CCC(N(C)C)CC6)=C7)=C(N3)C4=O)=NC5=C7O |
| 分子式 | C50H62N4O13 |
| 分子量 | 927.05 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | dmDNA31 is a rifamycin-class antibiotic that inhibits bacterial DNA-dependent RNA polymerase with potent bactericidal activity against S. aureus[1]. [1]. Peck M, et al. A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti-Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers. Antimicrob Agents Chemother. 2019 May 24;63(6). |
