IAA-94 (R(+)-Methylindazone) 是一种有效的上皮氯化物通道的茚满氧基乙酸阻滞剂。
| Cas No. | 54197-31-8 |
| 别名 | R-(+)-甲基吲唑酮,R(+)-IAA 94 |
| 化学名 | 2-[[(2R)-6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl]oxy]-acetic acid |
| Canonical SMILES | ClC1=C(C([C@](C2CCCC2)(C)C3)=O)C3=CC(OCC(O)=O)=C1Cl |
| 分子式 | C17H18Cl2O4 |
| 分子量 | 357.2 |
| 溶解度 | ≤15mg/ml in ethanol;15mg/ml in DMSO;15mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | R(+)-IAA-94 is a potent indanyloxyacetic acid blocker of epithelial chloride channels.IC50 value:Target: IAA-94 has been employed in modulating chloride channel function to probe the dynamics and function of the channels. The high affinity of IAA-94 for the chloride channel has been exploited for isolation and reconstitution of these proteins. References:
[1]. Landry DW, et al. Epithelial chloride channel. Development of inhibitory ligands. J Gen Physiol. 1987 Dec;90(6):779-98.
[2]. Landry DW, et al. Purification and reconstitution of chloride channels from kidney and trachea. Science. 1989 Jun 23;244(4911):1469-72.
[3]. Weber-Schurholz S, et al. Indanyloxyacetic acid-sensitive chloride channels from outer membranes of skeletal muscle. J Biol Chem. 1993 Jan 5;268(1):547-51. |
